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The Long-term Natural History of the Weekly Symptomatic Status of Bipolar I Disorder
Archives of General Psychiatry · 2002 · Vol. 59(6) · pp. 530–530
Lewis L. Judd✉(Washington University in St. Louis)Hagop S. Akiskal(Brown University)Pamela J. Schettler(Columbia University)Jean Endicott(Washington University in St. Louis)Jack D. Maser(Columbia University)David A. Solomon(Brown University)Andrew C. Leon(University of California, San Diego)John A. Rice(Brown University)Martin B. Keller(University of California, San Diego)
Abstract
The longitudinal weekly symptomatic course of BP-I is chronic. Overall, the symptomatic structure is primarily depressive rather than manic, and subsyndromal and minor affective symptoms predominate. Symptom severity levels fluctuate, often within the same patient over time. Bipolar I disorder is expressed as a dimensional illness featuring the full range (spectrum) of affective symptom severity and polarity.
Bipolar Disorder and TreatmentSchizophrenia research and treatmentElectroconvulsive Therapy StudiesManiaBipolar disorderDepression (economics)HypomaniaAsymptomaticProspective cohort studyPsychiatryDepressive symptomsMedicineBipolar I disorder
MeSH terms
AdolescentAdultAgedBipolar DisorderChronic DiseaseDepressive DisorderFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedPrognosisProspective StudiesPsychiatric Status Rating Scales
Funding
- University of California, San Diego
- National Institute of Mental Health
Citations
2,088
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36.31
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30
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References
The Longitudinal Interval Follow-up Evaluation
Archives of General Psychiatry · 1987 · 1,645 citations
Manic Depressive Insanity and Paranoia
The Journal of Nervous and Mental Disease · 1921 · 1,307 citations
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