article Open AccessTop 10% cited

Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques

American Journal Of Pathology · 2003 · Vol. 163(6) · pp. 2347–2370

Thomas W. Geisbert(United States Army Medical Research Institute of Infectious Diseases)Lisa E. Hensley(United States Army Medical Research Institute of Infectious Diseases)Thomas Larsen(United States Army Medical Research Institute of Infectious Diseases)Howard A. Young(Center for Cancer Research)Douglas S. Reed(United States Army Medical Research Institute of Infectious Diseases)Joan B. Geisbert✉(United States Army Medical Research Institute of Infectious Diseases)Dana Scott(United States Army Medical Research Institute of Infectious Diseases)Elliott Kagan(Uniformed Services University of the Health Sciences)Peter B. Jahrling(United States Army Medical Research Institute of Infectious Diseases)Kelly J. Davis(United States Army Medical Research Institute of Infectious Diseases)

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Viral Infections and Outbreaks Research Hepatitis B Virus Studies Viral Infections and VectorsEbola Hemorrhagic FeverEbola virusBiologyImmunologyBystander effectApoptosisPeripheral blood mononuclear cellPathogenesisInnate immune systemVirology

MeSH terms

AnimalsDendritic CellsEndotoxinsFlow CytometryLeukocyte CountLongitudinal StudiesMacaca fascicularisMaleNitratesTime FactorsViremiaCytokinesCritical IllnessChemokinesHemorrhagic Fever, Ebola

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568

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Human Fatal Zaire Ebola Virus Infection Is Associated with an Aberrant Innate Immunity and with Massive Lymphocyte Apoptosis