article Open AccessTop 1% cited
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs
Nature Structural & Molecular Biology · 2011 · Vol. 18(10) · pp. 1139–1146
David M. Garcia✉(Howard Hughes Medical Institute)Daehyun Baek(Whitehead Institute for Biomedical Research)Chanseok Shin(Whitehead Institute for Biomedical Research)George W. Bell(Whitehead Institute for Biomedical Research)Andrew Grimson(Whitehead Institute for Biomedical Research)David P. Bartel(Massachusetts Institute of Technology)
MicroRNA in disease regulationAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliverymicroRNABiologySmall interfering RNAPsychological repressionPairingComputational biologyGene silencingRNA interferenceCell biologyGene
MeSH terms
AnimalsHeLa CellsHumansCaenorhabditis elegans3' Untranslated RegionsMicroRNAs
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References
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Nature · 2004 · 10,802 citations
Most mammalian mRNAs are conserved targets of microRNAs
Genome Research · 2008 · 8,505 citations
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Nature Genetics · 2005 · 4,610 citations
Thermodynamic Parameters for an Expanded Nearest-Neighbor Model for Formation of RNA Duplexes with Watson−Crick Base Pairs
Biochemistry · 1998 · 1,156 citations
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
Molecular Cell · 2007 · 3,788 citations
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