reviewTop 1% cited
Psychosis as a State of Aberrant Salience: A Framework Linking Biology, Phenomenology, and Pharmacology in Schizophrenia
American Journal of Psychiatry · 2002 · Vol. 160(1) · pp. 13–23
Shitij Kapur✉(Centre for Addiction and Mental Health)
Abstract
The article provides a heuristic framework for linking the psychological and biological in psychosis. Predictions of this hypothesis, particularly regarding the possibility of synergy between psychological and pharmacological therapies, are presented. The author describes how the hypothesis is complementary to other ideas about psychosis and also discusses its limitations.
Mental Health and PsychiatrySchizophrenia research and treatmentPsychosomatic Disorders and Their TreatmentsPsychosisSalience (neuroscience)PsychologyDopamine hypothesis of schizophreniaAntipsychoticPhenomenology (philosophy)CognitionPsychotherapistSchizophrenia (object-oriented programming)Neuroscience
MeSH terms
BrainCombined Modality TherapyDelusionsDopamineHallucinationsHumansPerceptual DistortionPsychotherapySchizophreniaSchizophrenic PsychologyAntipsychotic Agents
Citations
2,759
FWCI
240.27
field-weighted impact
References
174
Percentile
100%
vs. same field & year
Citations per year
Cited by
Acta Psychiatrica Scandinavica
Acta Psychiatrica Scandinavica · 2010 · 384 citations
Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications
Acta Psychiatrica Scandinavica · 2005 · 1,492 citations
Dopamine in Motivational Control: Rewarding, Aversive, and Alerting
Neuron · 2010 · 2,379 citations
Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring
Schizophrenia Bulletin · 2009 · 1,138 citations
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Schizophrenia Bulletin · 2009 · 2,637 citations
Moderation of the Effect of Adolescent-Onset Cannabis Use on Adult Psychosis by a Functional Polymorphism in the Catechol-O-Methyltransferase Gene: Longitudinal Evidence of a Gene X Environment Interaction
Biological Psychiatry · 2005 · 1,380 citations
The dysconnection hypothesis (2016)
Schizophrenia Research · 2016 · 597 citations
Gene-Environment Interactions in Schizophrenia: Review of Epidemiological Findings and Future Directions
Schizophrenia Bulletin · 2008 · 721 citations
References
Responses of monkey dopamine neurons during learning of behavioral reactions
Journal of Neurophysiology · 1992 · 989 citations
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Neuroscience · 2000 · 974 citations
Drug addiction as dopamine-dependent associative learning disorder
European Journal of Pharmacology · 1999 · 590 citations
Receptor activity and turnover of dopamine and noradrenaline after neuroleptics
European Journal of Pharmacology · 1970 · 1,037 citations
Putatively psychosis-prone subjects 10 years later.
Journal of Abnormal Psychology · 1994 · 965 citations
Reasoning in Deluded Schizophrenic and Paranoid Patients
The Journal of Nervous and Mental Disease · 1991 · 599 citations
Neurobehavioural mechanisms of reward and motivation
Current Opinion in Neurobiology · 1996 · 1,180 citations
Cognitive therapy for psychosis in schizophrenia: an effect size analysis
Schizophrenia Research · 2001 · 392 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.