review Open AccessTop 1% cited
The Pleiotropic Two-Component Regulatory System PhoP-PhoQ
Journal of Bacteriology · 2001 · Vol. 183(6) · pp. 1835–1842
Eduardo A. Groisman✉(Howard Hughes Medical Institute)
Abstract
PhoP-PhoQ is a two-component system that governs virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities in several gram-negative species. It consists of the inner membrane sensor PhoQ and the cytoplasmic regulator PhoP. The PhoP-PhoQ system is
Magnesium in Health and DiseaseBiologyComponent (thermodynamics)Escherichia coli ProteinsTwo-component regulatory systemCell biologyGeneticsComputational biologyBacterial proteinGeneMutant
MeSH terms
AnimalsBacterial ProteinsHumansHydrogen-Ion ConcentrationMagnesiumPromoter Regions, GeneticSalmonellaTranscription, GeneticVirulenceSignal TransductionGene Expression Regulation, BacterialMice
Funding
- Howard Hughes Medical Institute
Citations
875
FWCI
31.71
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References
90
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100%
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References
Two-Component Signal Transduction
Annual Review of Biochemistry · 2000 · 3,636 citations
PmrA–PmrB‐regulated genes necessary for 4‐aminoarabinose lipid A modification and polymyxin resistance
Molecular Microbiology · 1998 · 652 citations
Macrophage‐dependent induction of the <i>Salmonella</i> pathogenicity island 2 type III secretion system and its role in intracellular survival
Molecular Microbiology · 1998 · 632 citations
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