reviewTop 1% cited
Biochemistry of arsenic detoxification
FEBS Letters · 2002 · Vol. 529(1) · pp. 86–92
Barry P. Rosen✉(Wayne State University)
Abstract
All living organisms have systems for arsenic detoxification. The common themes are (a) uptake of As(V) in the form of arsenate by phosphate transporters, (b) uptake of As(III) in the form of arsenite by aquaglyceroporins, (c) reduction of As(V) to As(III) by arsenate reductases, and (d) extrusion or sequestration of As(III). While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.
Arsenic contamination and mitigationTrace Elements in HealthHeavy Metal Exposure and ToxicityArsenateArseniteArsenicDetoxification (alternative medicine)BiochemistryPhosphateChemistryBiology
MeSH terms
Amino Acid SequenceAnimalsArsenicBacteriaBiodegradation, EnvironmentalBiotransformationEukaryotic CellsHumansIon ChannelsInactivation, MetabolicMolecular Sequence DataMultienzyme ComplexesIon PumpsAquaporinsArsenite Transporting ATPases
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References
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
The EMBO Journal · 1982 · 5,305 citations
CLUSTAL: a package for performing multiple sequence alignment on a microcomputer
Gene · 1988 · 3,429 citations
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