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Interleukin 6 and Interleukin 8 as Potential Biomarkers for Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

Archives of Otolaryngology - Head and Neck Surgery · 2004 · Vol. 130(8) · pp. 929–929

Maie A.R. St. John✉(University of California, Los Angeles)Yang Li(University of California, Los Angeles)Xiaofeng ZhouPaul Denny(University of California, Los Angeles)Chih‐Ming HoCarlo MontemagnoWenyuan Shi(University of California, Los Angeles)Fengxia Qi(University of California, Los Angeles)Benjamin M. Wu(University of California, Los Angeles)Uttam K. Sinha(University of Southern California)Richard C. Jordan(University of California, San Francisco)Lawrence E. Wolinsky(University of California, Los Angeles)No-Hee Park(University of California, Los Angeles)Honghu Liu(University of California, Los Angeles)Elliot Abemayor(University of California, Los Angeles)David T. Wong(University of California, Los Angeles)

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Abstract

Our findings indicate that IL-8 in saliva and IL-6 in serum hold promise as biomarkers for OSCC. A saliva-based test could be a cost-effective adjunctive tool in the diagnosis and follow-up of patients with OSCC.

Salivary Gland Tumors Diagnosis and Treatment Head and Neck Cancer Studies NF-κB Signaling PathwaysSalivaLaser capture microdissectionMedicineMicrodissectionInterleukinInterleukin 8Real-time polymerase chain reactionBasal cellPathologyInternal medicine

MeSH terms

AdultCaliforniaCarcinoma, Squamous CellFemaleHumansMaleMiddle AgedMouthMouth NeoplasmsOropharyngeal NeoplasmsPredictive Value of TestsRNA, MessengerSalivaSensitivity and SpecificityBiomarkers, Tumor

Citations

426

FWCI

11.73

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99%

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Cited by

The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva