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Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta

Developmental Cell · 2003 · Vol. 4(1) · pp. 67–82

Motoyuki Itoh(Eunice Kennedy Shriver National Institute of Child Health and Human Development)Cheol‐Hee Kim(Eunice Kennedy Shriver National Institute of Child Health and Human Development)Gregory R. Palardy(Eunice Kennedy Shriver National Institute of Child Health and Human Development)Takaya Oda(National Human Genome Research Institute)Yun‐Jin Jiang(Cancer Research UK)Donovan T. Maust(Eunice Kennedy Shriver National Institute of Child Health and Human Development)Sang‐Yeob Yeo(Eunice Kennedy Shriver National Institute of Child Health and Human Development)Kevin L. Lorick(Protein Express (United States))Gavin J. Wright(Cancer Research UK)Linda Ariza‐McNaughton(Cancer Research UK)Allan M. Weissman(Protein Express (United States))Julian Lewis(Cancer Research UK)Settara C. Chandrasekharappa(National Human Genome Research Institute)Ajay Chitnis✉(Eunice Kennedy Shriver National Institute of Child Health and Human Development)

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Developmental Biology and Gene Regulation Zebrafish Biomedical Research Applications Neurogenesis and neuroplasticity mechanismsNotch signaling pathwayBiologyHes3 signaling axisUbiquitin ligaseCell biologyNotch proteinsUbiquitinInternalizationSignal transductionEndocytosis

MeSH terms

AnimalsCell DifferentiationEndocytosisGene Expression RegulationLigasesMembrane ProteinsMolecular Sequence DataNeuronsPhenotypeRNA, MessengerSpinal CordZebrafishBlotting, WesternSignal TransductionIn Situ Hybridization

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Notch signaling: simplicity in design, versatility in function