review Open AccessTop 1% cited
16S rRNA Gene Sequencing for Bacterial Identification in the Diagnostic Laboratory: Pluses, Perils, and Pitfalls
Journal of Clinical Microbiology · 2007 · Vol. 45(9) · pp. 2761–2764
J. Michael Janda✉(California Department of Public Health)Sharon L. Abbott(California Department of Public Health)
Abstract
The use of 16S rRNA gene sequences to study bacterial phylogeny and taxonomy has been by far the most common housekeeping genetic marker used for a number of reasons. These reasons include (i) its presence in almost all bacteria, often existing as a multigene family, or operons; (ii) the function of
Genomics and Phylogenetic StudiesBacterial Identification and Susceptibility TestingMycobacterium research and diagnosis16S ribosomal RNAIdentification (biology)BiologyComputational biologyPolymerase chain reactionMicrobiologyGeneGeneticsEcology
MeSH terms
BacteriaBacterial InfectionsDNA, BacterialDNA, RibosomalHumansRNA, Ribosomal, 16SSequence Analysis, DNAMolecular Diagnostic Techniques
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References
Taxonomic Note: A Place for DNA-DNA Reassociation and 16S rRNA Sequence Analysis in the Present Species Definition in Bacteriology
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · 1994 · 6,996 citations
16S Ribosomal DNA Sequence Analysis of a Large Collection of Environmental and Clinical Unidentifiable Bacterial Isolates
Journal of Clinical Microbiology · 2000 · 1,051 citations
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