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The Development and Application of Optogenetics

Annual Review of Neuroscience · 2011 · Vol. 34(1) · pp. 389–412

Lief E. Fenno✉(Howard Hughes Medical Institute)Ofer Yizhar(Howard Hughes Medical Institute)Karl Deisseroth(Howard Hughes Medical Institute)

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Abstract

Genetically encoded, single-component optogenetic tools have made a significant impact on neuroscience, enabling specific modulation of selected cells within complex neural tissues. As the optogenetic toolbox contents grow and diversify, the opportunities for neuroscience continue to grow. In this review, we outline the development of currently available single-component optogenetic tools and summarize the application of various optogenetic tools in diverse model organisms.

Photoreceptor and optogenetics research Molecular Communication and Nanonetworks Neuroscience and Neural EngineeringOptogeneticsNeuroscienceToolboxComponent (thermodynamics)Computer scienceBiology

MeSH terms

AnimalsGenetic EngineeringHumansModels, GeneticNerve NetNeural InhibitionNeuronsNeurosciencesAnimals, Genetically ModifiedOpsinsLight Signal Transduction

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