articleTop 1% cited
Detailed Identification of Plasma Proteins Adsorbed on Copolymer Nanoparticles
Angewandte Chemie · 2007 · Vol. 119(30) · pp. 5856–5858
Tommy Cedervall(University College Dublin)Iseult Lynch✉(University College Dublin)Martina Foy(University College Dublin)Tord Berggård(Lund University)Seamas C. Donnelly(University College Dublin)Gerard Cagney(University College Dublin)Sara Linse(Lund University)Kenneth A. Dawson(University College Dublin)
Abstract
Blutsverwandte: Nanopartikel, die in den Blutstrom eintreten, lagern an ihrer Oberfläche Proteine an. Vier Apolipoproteine wurden mithilfe von Copolymernanopartikeln beim Zentrifugieren vollständig zurückerhalten (siehe Elektropherogramm); ihre Wechselwirkung mit den Nanopartikeln ist stärker als die anderer Plasmaproteine, die in höheren Konzentrationen vorkommen.
Nanoparticle-Based Drug DeliveryMass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and ApplicationsCopolymerChemistryPolymer scienceNanotechnologyMaterials scienceOrganic chemistryPolymer
MeSH terms
AdsorptionBlood ProteinsCentrifugationElectrophoresis, Polyacrylamide GelPolymersNanoparticles
Citations
655
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17.73
field-weighted impact
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21
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References
Plasma lipoproteins: apolipoprotein structure and function.
Journal of Lipid Research · 1984 · 1,154 citations
The potential environmental impact of engineered nanomaterials
Nature Biotechnology · 2003 · 2,165 citations
Toxic Potential of Materials at the Nanolevel
Science · 2006 · 9,132 citations
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