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Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

Archives of Neurology · 2010 · Vol. 67(10) · pp. 1187–94

Dimitrios Karussis✉Clementine KarageorgiouAdi Vaknin‐DembinskyBasan Gowda-KurkalliJohn M. GomoriIbrahim KassisJeff W. M. BultePanayiota PetrouTamir Ben‐HurOded AbramskyShimon Slavin

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Abstract

Transplantation of MSCs in patients with MS and ALS is a clinically feasible and relatively safe procedure and induces immediate immunomodulatory effects. Trial Registration clinicaltrials.gov Identifier: NCT00781872.

Amyotrophic Lateral Sclerosis Research Mesenchymal stem cell research Biomedical Ethics and RegulationMedicineMesenchymal stem cellExpanded Disability Status ScaleMultiple sclerosisMagnetic resonance imagingAdverse effectAmyotrophic lateral sclerosisTransplantationInternal medicinePathology

MeSH terms

AdultAmyotrophic Lateral SclerosisBrainDextransDisability EvaluationFemaleFlow CytometryFollow-Up StudiesHumansInjections, IntravenousInjections, SpinalLymphocytesMagnetic Resonance ImagingMaleMiddle Aged

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Cited by

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)