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Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents
Angewandte Chemie International Edition · 2007 · Vol. 46(46) · pp. 8748–8758
Chris V. Galliford✉(Northwestern University)Karl A. Scheidt(Northwestern University)
Abstract
The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.
Chemical Synthesis and AnalysisMicrobial Natural Products and BiosynthesisCarbohydrate Chemistry and SynthesisChemistryCombinatorial chemistryStructural motifAlkaloidStereochemistryBiochemistry
MeSH terms
Biological ProductsIndolesStructure-Activity RelationshipDrug DesignMolecular Structure
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References
Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids
European Journal of Organic Chemistry · 2003 · 1,435 citations
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