articleTop 1% cited
A Microwave-Assisted Click Chemistry Synthesis of 1,4-Disubstituted 1,2,3-Triazoles via a Copper(I)-Catalyzed Three-Component Reaction
Organic Letters · 2004 · Vol. 6(23) · pp. 4223–4225
Prasad Appukkuttan✉(Scripps Research Institute)Wim Dehaen(Scripps Research Institute)Valery V. Fokin(Scripps Research Institute)Erik V. Van der Eycken(Scripps Research Institute)
Abstract
A microwave-assisted three-component reaction was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from corresponding alkyl halides, sodium azide, and alkynes. This procedure eliminates the need to handle organic azides, as they are generated in situ, making this already powerful click process even more user-friendly and safe.
Click Chemistry and ApplicationsChemical Synthesis and AnalysisSynthesis and Characterization of Heterocyclic CompoundsChemistryClick chemistrySodium azideHalideComponent (thermodynamics)AlkylCombinatorial chemistryCatalysisAzideMicrowave
Funding
- Vlaamse regering
Citations
557
FWCI
15.05
field-weighted impact
References
12
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100%
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References
Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides
The Journal of Organic Chemistry · 2002 · 8,416 citations
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