article Open AccessTop 1% cited
Serotonin Transporter Promoter Gain-of-Function Genotypes Are Linked to Obsessive-Compulsive Disorder
The American Journal of Human Genetics · 2006 · Vol. 78(5) · pp. 815–826
Xian‐Zhang Hu(National Institute on Alcohol Abuse and Alcoholism)Robert H. Lipsky(National Institute on Alcohol Abuse and Alcoholism)Guanshan Zhu(National Institute on Alcohol Abuse and Alcoholism)Longina A. Akhtar(National Institute on Alcohol Abuse and Alcoholism)Julie Taubman(National Institute on Alcohol Abuse and Alcoholism)Benjamin D. Greenberg(Brown University)Ke Xu(National Institute on Alcohol Abuse and Alcoholism)Paul Arnold(Centre for Addiction and Mental Health)Margaret A. Richter(Centre for Addiction and Mental Health)James L. Kennedy(Centre for Addiction and Mental Health)Dennis L. Murphy(National Institute of Mental Health)David Goldman✉(National Institute on Alcohol Abuse and Alcoholism)
Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorAutism Spectrum Disorder ResearchSerotonin transporterObsessive compulsiveGenotypeFunction (biology)TransporterSerotonin Plasma Membrane Transport ProteinsSerotoninGain of functionGeneticsBiology
MeSH terms
AdultAnimalsBase SequenceCell LineFemaleGene FrequencyGenotypeHumansMaleMolecular Sequence DataObsessive-Compulsive DisorderPromoter Regions, GeneticTranscription, GeneticTransfectionCase-Control Studies
Funding
- University of Louisville
- National Institutes of Health
- National Institute of Mental Health
Citations
1,118
FWCI
88.27
field-weighted impact
References
52
Percentile
100%
vs. same field & year
Citations per year
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References
The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants
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Psychiatry Research · 1994 · 2,377 citations
Allelic Variation of Human Serotonin Transporter Gene Expression
Journal of Neurochemistry · 1996 · 2,220 citations
The Yale-Brown Obsessive Compulsive Scale
Archives of General Psychiatry · 1989 · 7,534 citations
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
Nature Neuroscience · 2005 · 1,964 citations
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Science · 2003 · 8,097 citations
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