article Open AccessTop 1% cited
Human non-contrast T1 values and correlation with histology in diffuse fibrosis
Heart · 2013 · Vol. 99(13) · pp. 932–937
Sacha Bull(University of Oxford)Steven K White(University College London)Stefan K. Piechnik(University of Oxford)Andrew Flett(University College London)Vanessa M. Ferreira(University of Oxford)Margaret Loudon(John Radcliffe Hospital)Jane M Francis(University of Oxford)Theodoros D. Karamitsos(University of Oxford)Bernard Prendergast(John Radcliffe Hospital)Matthew D. Robson(University of Oxford)Stefan Neubauer(University of Oxford)James Moon(University College London)Saul Myerson✉(John Radcliffe Hospital)
Abstract
Non-contrast T1 values are increased in patients with severe AS and further increase in symptomatic compared with asymptomatic patients. T1 values lengthened with greater LVMI and correlated with the degree of biopsy-quantified fibrosis. This may provide a useful clinical assessment of diffuse myocardial fibrosis in the future.
Cardiac Valve Diseases and TreatmentsCardiac Imaging and DiagnosticsAdvanced MRI Techniques and ApplicationsMedicineAsymptomaticMyocardial fibrosisFibrosisInternal medicineCardiologyMagnetic resonance imagingBiopsyAortic valve stenosisStenosis
MeSH terms
AgedAged, 80 and overAortic ValveAortic Valve StenosisBiopsyCollagenEnglandFemaleFibrosisHeart VentriclesHumansMagnetic Resonance ImagingMaleMiddle AgedMyocardium
Funding
- Alberta Innovates - Health Solutions
- National Institute for Health and Care Research
- British Heart Foundation
- Heart Research UK
- University of Oxford
- Alberta Innovates
- Medical Research Council
- Clarendon Fund
Citations
456
FWCI
30.33
field-weighted impact
References
33
Percentile
100%
vs. same field & year
Citations per year
References
ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Circulation · 2006 · 8,504 citations
Modified Look‐Locker inversion recovery (MOLLI) for high‐resolution <i>T</i><sub>1</sub> mapping of the heart
Magnetic Resonance in Medicine · 2004 · 1,332 citations
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