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Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study
Critical Care · 2009 · Vol. 13(3) · pp. R92–R92
Arnaldo Dubín✉(Sanatorio Otamendi y Miroli)Mario Omar PozoChristian A. Casabella(Sanatorio Otamendi y Miroli)Fernando PálizasGastón MuriasMiriam Moseinco(Sanatorio Otamendi y Miroli)Vanina Siham Kanoore Edul(Universidad Nacional de La Plata)Fernando PálizasElisa Estenssoro(Hospital Italiano La Plata)Can İnce(University of Amsterdam)
Abstract
Patients with septic shock showed severe sublingual microcirculatory alterations that failed to improve with the increases in MAP with norepinephrine. Nevertheless, there was a considerable interindividual variation. Our results suggest that the increase in MAP above 65 mmHg is not an adequate approach to improve microcirculatory perfusion and might be harmful in some patients.
Hemodynamic Monitoring and TherapyHeart Rate Variability and Autonomic ControlBlood Pressure and Hypertension StudiesMedicineBlood pressureNorepinephrineBlood flowProspective cohort studyIntensive care medicineAnesthesiaMicrocirculationCardiologyEmergency medicine
MeSH terms
Acid-Base EquilibriumAgedAnalysis of VarianceDose-Response Relationship, DrugFemaleHemodynamicsHumansMaleMicrocirculationMouth FloorNorepinephrineProspective StudiesShock, SepticVasoconstrictor Agents
Funding
- Agencia Nacional de Promoción Científica y Tecnológica
Citations
463
FWCI
22.09
field-weighted impact
References
37
Percentile
100%
vs. same field & year
Citations per year
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References
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Critical Care · 2007 · 822 citations
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Critical Care Medicine · 2004 · 1,242 citations
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Critical Care · 2005 · 744 citations
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Critical Care Medicine · 1992 · 4,805 citations
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