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Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States

Annals of Internal Medicine · 2002 · Vol. 137(12) · pp. 947–954

George Ostapowicz✉(Northwestern University)Robert J. Fontana(Northwestern University)Frank Vinholt Schiødt(Northwestern University)Anne M. Larson(Northwestern University)Timothy J. Davern(Northwestern University)Steven Han(Northwestern University)Timothy M. McCashland(Northwestern University)A. Obaid Shakil(Northwestern University)J. Eileen Hay(Northwestern University)Linda S. Hynan(Northwestern University)Jeffrey S. Crippin(University of Nebraska Medical Center)Andrés T. Blei(Northwestern University)Grace Samuel(Northwestern University)Joan Reisch(Northwestern University)William M. Lee(Northwestern University)and the U.S. Acute Liver Failure Study Group*

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Abstract

Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent apparent causes of acute liver failure. Apparent cause and coma grade at admission were associated with outcome. Although transplantation may improve patient survival, it was unavailable or unnecessary for most patients.

Liver Disease and Transplantation Drug-Induced Hepatotoxicity and Protection Hepatitis C virus researchMedicineLiver transplantationAcetaminophenInternal medicineProspective cohort studyComa (optics)Hepatitis CTransplantationAnesthesia

MeSH terms

AcetaminophenAdolescentAdultAge FactorsAgedFemaleHepatic EncephalopathyHepatitis AHepatitis BHumansMaleMiddle AgedPrognosisProspective StudiesTime Factors