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A genetic map of the mouse suitable for typing intraspecific crosses.

Genetics · 1992 · Vol. 131(2) · pp. 423–447

William F. Dietrich✉(Whitehead Institute for Biomedical Research)H Katz(Whitehead Institute for Biomedical Research)Stephen E. Lincoln(Whitehead Institute for Biomedical Research)Hee‐Sup Shin(Whitehead Institute for Biomedical Research)Jeffrey M. Friedman(Whitehead Institute for Biomedical Research)Nicholas C. Dracopoli(Whitehead Institute for Biomedical Research)Eric S. Lander(Whitehead Institute for Biomedical Research)

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Abstract

We report the construction of a genetic linkage map of the mouse, consisting entirely of genetic markers that can be rapidly typed by polymerase chain reaction and that show a high degree of polymorphism among inbred laboratory strains. Specifically, the map contains 317 simple sequence length polymorphisms at an average spacing of 4.3 cM and is detectably linked to approximately 99% of the mouse genome. In typical crosses between inbred laboratory strains, about 50% of the markers are polymorphic, making it straightforward to follow inheritance in almost any cross.

Genetic Mapping and Diversity in Plants and Animals Animal Genetics and Reproduction Chromosomal and Genetic VariationsBiologyIntraspecific competitionGeneticsTypingEvolutionary biologyZoology

MeSH terms

AnimalsBase SequenceChromosome MappingGenetic MarkersGenetic LinkageMice, Inbred StrainsMolecular Sequence DataRepetitive Sequences, Nucleic AcidPolymorphism, Restriction Fragment LengthPolymerase Chain ReactionGenomeMice

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