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PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies

Clinical Cancer Research · 2013 · Vol. 19(13) · pp. 3462–3473

Benjamin J. Chen(UMass Memorial Medical Center)Bjoern Chapuy(Harvard University)Jing Ouyang(Harvard University)Heather H. Sun(University of Massachusetts Chan Medical School)Margaretha G.M. Roemer(University of Massachusetts Chan Medical School)Mina L. Xu(Brigham and Women's Hospital)Hongbo Yu(Yale University)Christopher D.�M. Fletcher(University of Massachusetts Chan Medical School)Gordon J. Freeman(University of Massachusetts Chan Medical School)Margaret A. Shipp(Dana-Farber Cancer Institute)Scott J. Rodig✉(Brigham and Women's Hospital)

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Abstract

Certain aggressive B-cell lymphomas and virus- and immunodeficiency-associated malignancies associated with an ineffective T-cell immune response express PD-L1 on tumor cells and infiltrating macrophages. These results identify a group of neoplasms that should be considered for PD-1/PD-L1-directed therapies, and validate methods to detect PD-L1 in FFPE tissue biopsies.

Cancer Immunotherapy and Biomarkers Lymphoma Diagnosis and Treatment Viral-associated cancers and disordersB cellLymphomaVirusExpression (computer science)MedicineCancer researchImmunologyBiologyVirologyAntibody