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A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes

Genome biology · 2004 · Vol. 5(2) · pp. R7–R7

Eugene V. Koonin✉(National Center for Biotechnology Information)Natalie D. Fedorova(National Center for Biotechnology Information)John D. Jackson(National Center for Biotechnology Information)Aviva R. Jacobs(National Institutes of Health)Dmitri M. Krylov(National Institutes of Health)Kira S. Makarova(National Institutes of Health)Raja Mazumder(Georgetown University)Sergei Mekhedov(National Center for Biotechnology Information)A. N. NIKOL'SKAYA(National Institutes of Health)B Sridhar Rao(National Institutes of Health)Igor B. Rogozin(National Institutes of Health)Sergei Smirnov(National Center for Biotechnology Information)Alexander V. Sorokin(National Institutes of Health)Alexander V. Sverdlov(National Center for Biotechnology Information)Sona Vasudevan(National Center for Biotechnology Information)Yuri I. Wolf(National Institutes of Health)Jodie J Yin(National Institutes of Health)Darren A. Natale(National Institutes of Health)

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Abstract

The KOG analysis reveals a conserved core of largely essential eukaryotic genes as well as major diversification and innovation associated with evolution of eukaryotic genomes. The results provide quantitative support for major trends of eukaryotic evolution noticed previously at the qualitative level and a basis for detailed reconstruction of evolution of eukaryotic genomes and biology of ancestral forms.

Genomics and Phylogenetic Studies Chromosomal and Genetic Variations RNA and protein synthesis mechanismsBiologyGenomeGeneticsGeneCaenorhabditis elegansSchizosaccharomyces pombeComputational biologyComparative genomicsConserved sequenceDrosophila melanogaster

MeSH terms

AnimalsEukaryotic CellsHumansPhylogenyProkaryotic CellsProteinsYeastsGenomeCaenorhabditis elegansGene DeletionProtein Structure, TertiaryEvolution, MolecularSequence Analysis, Protein

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