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Identification of the <i>Bcl</i>I polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids <i>in vivo</i> and body mass index
Clinical Endocrinology · 2003 · Vol. 59(5) · pp. 585–592
Elisabeth F. C. van Rossum(Erasmus MC)Jan W. Koper✉Annewieke W. van den BeldAndré G. UitterlindenPascal ArpWietske A. EsterJ. A. M. J. L. JanssenAlbert O. Brinkmann(Erasmus MC)Frank H. de JongDiederick E. Grobbee(Utrecht University)Huibert A. P. PolsSteven W. J. Lamberts
Abstract
We characterized a BclI-RFLP (restriction fragment length polymorphism) of the GR gene as a C/G polymorphism in intron 2 of which the G-allele was associated with hypersensitivity to glucocorticoids. This resulted in a lower BMI in older individuals in general, while our study in elderly males suggests that the lower BMI is probably due to a greater loss of lean mass during the ageing process.
Adrenal Hormones and DisordersElectrolyte and hormonal disordersEstrogen and related hormone effectsGlucocorticoid receptorEndocrinologyInternal medicineGlucocorticoidIn vivoBody mass indexBiologyPolymorphism (computer science)GeneReceptor
MeSH terms
AgedBody CompositionBody ConstitutionDexamethasoneFemaleGlucocorticoidsHeterozygoteHomozygoteHumansMaleReceptors, GlucocorticoidPolymorphism, Restriction Fragment LengthRestriction MappingDeoxyribonucleases, Type II Site-SpecificBody Mass Index
Citations
314
FWCI
7.16
field-weighted impact
References
24
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98%
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Cited by
Glucocorticoids and Cardiovascular Disease
European Journal of Endocrinology · 2007 · 525 citations
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