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Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

Journal of Neurology Neurosurgery & Psychiatry · 2010 · Vol. 82(2) · pp. 126–135

Alida A. Gouw✉(Amsterdam UMC Location VUmc)Alexandra Seewann(Medical University of Graz)Wiesje M. van der Flier(Amsterdam UMC Location VUmc)Frederik Barkhof(Amsterdam UMC Location VUmc)Annemieke J.M. Rozemüller(Amsterdam UMC Location VUmc)Philip Scheltens(Amsterdam UMC Location VUmc)Jeroen Geurts(Amsterdam UMC Location VUmc)

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Abstract

Pathological substrates of WMH are heterogeneous in nature and severity, which may partly explain the weak clinicoradiological associations found in SVD. Lacunes and microbleeds have been relatively understudied and need to be further investigated. Future studies should also take into account 'MRI invisible' SVD features and consider the use of, for example, quantitative MRI techniques, to increase the sensitivity of MRI for these abnormalities and study their effects on clinical functioning.

Intracerebral and Subarachnoid Hemorrhage Research Acute Ischemic Stroke Management Neurological Disease Mechanisms and TreatmentsPathologyCerebral amyloid angiopathyHyperintensityMedicineWhite matterPerivascular spaceHistopathologyMagnetic resonance imagingPathologicalNeuropathology