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Doubly Robust Estimation of Causal Effects

American Journal of Epidemiology · 2011 · Vol. 173(7) · pp. 761–767
Michele Jönsson FunkDaniel WestreichChris WiesenTil Stürmer‎M. Alan BrookhartMarie Davidian

Abstract

Doubly robust estimation combines a form of outcome regression with a model for the exposure (i.e., the propensity score) to estimate the causal effect of an exposure on an outcome. When used individually to estimate a causal effect, both outcome regression and propensity score methods are unbiased only if the statistical model is correctly specified. The doubly robust estimator combines these 2 approaches such that only 1 of the 2 models need be correctly specified to obtain an unbiased effect estimator. In this introduction to doubly robust estimators, the authors present a conceptual overview of doubly robust estimation, a simple worked example, results from a simulation study examining performance of estimated and bootstrapped standard errors, and a discussion of the potential advantages and limitations of this method. The supplementary material for this paper, which is posted on the Journal's Web site (http://aje.oupjournals.org/), includes a demonstration of the doubly robust property (Web Appendix 1) and a description of a SAS macro (SAS Institute, Inc., Cary, North Carolina) for doubly robust estimation, available for download at http://www.unc.edu/~mfunk/dr/.

Advanced Causal Inference TechniquesStatistical Methods and InferenceStatistical Methods and Bayesian InferenceEstimatorPropensity score matchingStatisticsRobust statisticsEstimationComputer scienceRobust regressionCausal inferenceRegressionOutcome (game theory)

MeSH terms

Computer SimulationEpidemiologic MethodsHumansMonte Carlo MethodRegression AnalysisModels, StatisticalCausalityConfounding Factors, EpidemiologicConfidence IntervalsLikelihood FunctionsPropensity Score

Funding

  • North Carolina State University
  • Agency for Healthcare Research and Quality
  • University of North Carolina at Chapel Hill
  • National Institute on Aging
  • National Institute of Allergy and Infectious Diseases
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