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The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort

Journal of Neurology Neurosurgery & Psychiatry · 2013 · Vol. 84(11) · pp. 1258–1264

Caroline H. Williams‐Gray✉(University of Cambridge)Sarah Mason(University of Cambridge)Jonathan Evans(University of Cambridge)Thomas Foltynie(Sobell House)Carol Brayne(University of Cambridge)Trevor W. Robbins(University of Cambridge)Roger A. Barker(University of Cambridge)

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Abstract

(1) outlook in PD is heterogeneous, with most dying or developing dementia or postural instability by 10 years from diagnosis, but a quarter still doing well, with preserved mobility and intact cognition; (2) death is not directly related to PD in the majority; (3) baseline clinical and genetic variables are predictive of outcome and may be helpful in selecting patients for clinical trials.

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Balance, Gait, and Falls PreventionDementiaMedicineRotterdam StudyCohortPopulationPediatricsCohort studyProportional hazards modelDiseaseHazard ratio