articleTop 10% cited
Stoffwechselprodukte von Mikroorganismen. 98. Mitteilung. Phosphinothricin und Phosphinothricyl‐Alanyl‐Alanin
Helvetica Chimica Acta · 1972 · Vol. 55(1) · pp. 224–239
E. Bayer✉(University of Tübingen)K. H. Gugel(University of Tübingen)K. Hägele(University of Tübingen)Hanspaul Hagenmaier(University of Tübingen)S. Jessipow(University of Tübingen)W. A. König(University of Tübingen)H Zähner(University of Tübingen)
Abstract
Abstract From cultures of Streptomyces viridochromogenes a new antibiotic, phosphinothricylalanyl‐alanine, has been isolated. The new amino acid phosphinothricin is 2‐amino‐4‐methyl‐phosphino‐butyric acid, its structure is confirmed by synthesis. The tripeptide is highly active against Gram ‐positive and Gram ‐negative bacteria and against the fungus Botrytis cinerea . Phosphinothricin is an active glutamine synthetase inhibitor.
Organophosphorus compounds synthesisAmino Acid Enzymes and MetabolismMetabolism and Genetic DisordersChemistryTripeptideStereochemistryGlutamineBotrytis cinereaAmino acidBiochemistryBotany
MeSH terms
AlanineAminobutyratesAnti-Bacterial AgentsMicrobial Sensitivity TestsPeptidesPhosphinic AcidsStreptomyces
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References
Human fibrinopeptides isolation, characterization and structure
Biochimica et Biophysica Acta (BBA) - General Subjects · 1966 · 426 citations
A Protein Sequenator
European Journal of Biochemistry · 1967 · 2,841 citations
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