article Open AccessTop 1% cited
Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients
Diabetes · 2008 · Vol. 57(5) · pp. 1349–1354
Antonio Ceriello✉(University Hospital Coventry)Katherine Esposito(University of Naples Federico II)Ludovica PiconiMichael A. Ihnat(Translational Research in Oncology)Jessica E. Thorpe(University of Oklahoma Health Sciences Center)Roberto Testa(Istituto Nazionale di Riposo e Cura per Anziani)Massimo Boemi(Istituti di Ricovero e Cura a Carattere Scientifico)Dario Giugliano(University of Naples Federico II)
Abstract
These data suggest that oscillating glucose can have more deleterious effects than constant high glucose on endothelial function and oxidative stress, two key players in favoring cardiovascular complications in diabetes. Concomitant vitamin C infusion can reverse this impairment.
Advanced Glycation End Products researchCardiovascular Health and Disease PreventionBlood Pressure and Hypertension StudiesInternal medicineEndocrinologyOxidative stressEndothelial dysfunctionDiabetes mellitusNitrotyrosineMedicineBasal (medicine)Type 2 diabetesGlucose clamp technique
MeSH terms
Blood GlucoseDiabetes Mellitus, Type 2Endothelium, VascularFemaleGlycated HemoglobinHomeostasisHumansMaleMiddle AgedOscillometryReference ValuesSomatostatinVasodilationOxidative Stress
Citations
1,289
FWCI
28.16
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
References
Biochemistry and molecular cell biology of diabetic complications
Nature · 2001 · 8,964 citations
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
The Lancet · 1998 · 19,985 citations
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
New England Journal of Medicine · 1993 · 24,605 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.