articleTop 1% cited
Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury
Nephrology Dialysis Transplantation · 2011 · Vol. 26(5) · pp. 1474–1483
Stefano Gatti✉(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)Stefania Bruno(University of Turin)Maria Chiara Deregibus(University of Turin)Andrea Sordi(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)Vincenzo Cantaluppi(University of Turin)Ciro Tetta(Fresenius Medical Care (Germany))Giovanni Camussi(University of Turin)
Abstract
MVs released from MSCs protect from AKI induced by ischaemia reperfusion injury and from subsequent chronic renal damage. This suggest that MVs could be exploited as a potential new therapeutic approach.
Extracellular vesicles in diseaseMesenchymal stem cell researchMicroRNA in disease regulationMedicineMicrovesiclesParacrine signallingMesenchymal stem cellAcute kidney injuryKidneyIschemiaRenal stem cellReperfusion injuryKidney disease
MeSH terms
AdultAnimalsCell DifferentiationCells, CulturedHumansKidney Failure, ChronicKidney TubulesMaleReperfusion InjuryRats, Sprague-DawleyMesenchymal Stem Cell TransplantationCell ProliferationRatsCell-Derived MicroparticlesAcute Kidney Injury
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References
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American Journal of Physiology-Renal Physiology · 2005 · 1,183 citations
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Nature Cell Biology · 2007 · 12,686 citations
Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication
Leukemia · 2006 · 1,330 citations
Mesenchymal Stem Cells Are Renotropic, Helping to Repair the Kidney and Improve Function in Acute Renal Failure
Journal of the American Society of Nephrology · 2004 · 754 citations
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Journal of Cellular Biochemistry · 2006 · 2,967 citations
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