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Effect of preoperative chemotherapy on the outcome of women with operable breast cancer.

Journal of Clinical Oncology · 1998 · Vol. 16(8) · pp. 2672–2685

Bernard Fisher✉(NSABP Foundation)John BryantNorman WolmarkE.P. MamounasA BrownEdwin R. FisherD. Lawrence WickerhamMirsada BegovičArthur P. DeCillisA. RobidouxRichard G. MargoleseAnatolio B. CruzJames L. HoehnAlan LeesN V DimitrovHarry D. Bear

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Abstract

Preoperative chemotherapy is as effective as postoperative chemotherapy, permits more lumpectomies, is appropriate for the treatment of certain patients with stages I and II disease, and can be used to study breast cancer biology. Tumor response to preoperative chemotherapy correlates with outcome and could be a surrogate for evaluating the effect of chemotherapy on micrometastases; however, knowledge of such a response provided little prognostic information beyond that which resulted from postoperative therapy.

Breast Cancer Treatment Studies Colorectal and Anal Carcinomas Endometrial and Cervical Cancer TreatmentsMedicineChemotherapyBreast cancerOncologyInternal medicineCancerGynecology

MeSH terms

Antineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCombined Modality TherapyCyclophosphamideDoxorubicinFemaleHumansMiddle AgedPrognosisSurvival RateProportional Hazards ModelsDisease-Free Survival

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