articleTop 10% cited
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF- and IL-17
Lara D. Veeken · 2008 · Vol. 47(11) · pp. 1635–1640
Abstract
IL-6/sIL-6R directly induced RANKL expression in RA-FLS and it is essential for RANKL induction by TNF-alpha and IL-17. Moreover, RANKL induction by IL-6/sIL-6R is mediated by the janus kinase/STAT signalling pathway.
NF-κB Signaling PathwaysCytokine Signaling Pathways and InteractionsBone Metabolism and DiseasesRANKLMedicineTumor necrosis factor alphaMolecular biologyActivator (genetics)STAT proteinCancer researchPhosphorylationReceptorInternal medicine
MeSH terms
Antibodies, MonoclonalArthritis, RheumatoidCells, CulturedFibroblastsFlavonoidsHumansImmunohistochemistryPhosphorylationRecombinant ProteinsRNA, MessengerSesquiterpenesStimulation, ChemicalSynovial MembraneTumor Necrosis Factor-alphaBlotting, Western
Funding
- Tokyo Medical and Dental University
Citations
352
FWCI
5.28
field-weighted impact
References
32
Percentile
96%
vs. same field & year
Citations per year
References
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Annals of the Rheumatic Diseases · 2007 · 740 citations
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