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Apparently conclusive meta-analyses may be inconclusive—Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses
International Journal of Epidemiology · 2008 · Vol. 38(1) · pp. 287–298
Jesper Brok✉(Rigshospitalet)Kristian Thorlund(Copenhagen University Hospital)Jørn Wetterslev(Copenhagen University Hospital)Christian Gluud(Rigshospitalet)
Abstract
Many apparently conclusive Cochrane neonatal meta-analyses may become inconclusive when the statistical analyses take into account the risk of random error due to repetitive testing.
Meta-analysis and systematic reviewsHemodynamic Monitoring and TherapyStatistical Methods in Clinical TrialsMeta-analysisRandom effects modelStudy heterogeneityMedicineStatisticStatisticsRelative riskRandomized controlled trialSample size determinationConfidence interval
MeSH terms
Data Interpretation, StatisticalHumansInfant, NewbornInfant, Newborn, DiseasesReview Literature as TopicMeta-Analysis as TopicRandomized Controlled Trials as TopicSample Size
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