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HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy

Neurology · 2010 · Vol. 75(23) · pp. 2087–2096

Robert K. Heaton✉(Johns Hopkins University)David B. Clifford(Johns Hopkins University)Donald Franklin(Johns Hopkins University)Steven Paul Woods(Johns Hopkins University)Christopher F. Ake(Johns Hopkins University)Florin Vaida(Johns Hopkins University)Ronald J. Ellis(Johns Hopkins University)Scott Letendre(Johns Hopkins University)Thomas D. Marcotte(Johns Hopkins University)J. Hampton Atkinson(Johns Hopkins University)Mónica Rivera Mindt(Johns Hopkins University)Ofilio Vigil(Johns Hopkins University)Michael Taylor(Johns Hopkins University)Ann C. Collier(Johns Hopkins University)Christina M. Marra(Johns Hopkins University)Benjamin B. Gelman(Johns Hopkins University)Justin C. McArthur(Johns Hopkins University)Susan Morgello(Johns Hopkins University)David M. Simpson(Johns Hopkins University)J. Allen McCutchan(Johns Hopkins University)Ian Abramson(Johns Hopkins University)Anthony Gamst(Johns Hopkins University)Christine Fennema‐Notestine(Johns Hopkins University)Terry L. Jernigan(Johns Hopkins University)J. Wong(Johns Hopkins University)Igor Grant(Johns Hopkins University)For the CHARTER Group

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Abstract

The most severe HAND diagnosis (HAD) was rare, but milder forms of impairment remained common, even among those receiving CART who had minimal comorbidities. Future studies should clarify whether early disease events (e.g., profound CD4 decline) may trigger chronic CNS changes, and whether early CART prevents or reverses these changes.

HIV Research and Treatment HIV-related health complications and treatments Cytomegalovirus and herpesvirus researchNeurocognitiveMedicineComorbidityCartDementiaInternal medicinePediatricsDiseasePsychiatryCognition

MeSH terms

Activities of Daily LivingAdultAlgorithmsCognition DisordersDisability EvaluationEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedNeurologic ExaminationNeuropsychological TestsPsychiatric Status Rating ScalesRetrospective StudiesModels, Statistical