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Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum β-lactamases in the UK

Journal of Antimicrobial Chemotherapy · 2004 · Vol. 54(4) · pp. 735–743

Neil Woodford✉(Health Protection Agency)M. E. WardMary E. KaufmannJane F. TurtonElizabeth J. FaganDeborah JamesAlan P. JohnsonRachel PikeM. WarnerT. CheastyA. PearsonS. HarryJ. B. LeachAnne LoughreyJ.A. LowesR. E. WarrenDavid M. Livermore

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Abstract

CTX-M-producing E. coli are a rapidly developing problem in the UK, with CTX-M-15 particularly common. The diversity of producers and geographical scatter of referring laboratories indicates wide dissemination of blaCTX-M genes. Because of the public health implications, including for the treatment of community-acquired urinary tract infections, the spread of these strains--and CTX-M-15 beta-lactamase in particular--merits close monitoring.

Antibiotic Resistance in Bacteria Bacterial biofilms and quorum sensing Pharmaceutical and Antibiotic Environmental ImpactsCeftazidimeCefotaximeEscherichia coliBiologyMicrobiologyAgar dilutionImipenemEtestTetracyclineBeta-lactamase

MeSH terms

AllelesAnti-Bacterial Agentsbeta-LactamasesConjugation, GeneticCross InfectionEscherichia coliEscherichia coli InfectionsGenes, BacterialUnited KingdomHumansMicrobial Sensitivity TestsPhenotypeElectrophoresis, Gel, Pulsed-FieldCommunity-Acquired InfectionsDrug Resistance, Bacterial

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470

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Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum β-lactamases