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Ultrasound Assessment of Flow-Mediated Dilation

Hypertension · 2010 · Vol. 55(5) · pp. 1075–1085
Ryan A. HarrisSteven K. NishiyamaD. Walter WrayRussell S. Richardson

Abstract

Developed in 1992, the flow-mediated dilation test is now the most commonly used noninvasive assessment of vascular endothelial function in humans. Since its inception, scientists have refined their understanding of the physiology, analysis, and interpretation of this measurement. Recently, a significant growth of knowledge has added to our understanding and implementation of this clinically relevant research methodology. Therefore, this tutorial provides timely insight into recent advances and practical information related to the ultrasonic assessment of vascular endothelial function in humans.

Cardiovascular Health and Disease PreventionThermoregulation and physiological responsesOptical Imaging and Spectroscopy TechniquesUltrasoundDilation (metric space)MedicineFunction (biology)Computer scienceIntensive care medicineData scienceNeuroscienceMedical physicsRadiology

MeSH terms

Arterial Occlusive DiseasesBlood Flow VelocityCaffeineCardiovascular DiseasesEndothelium, VascularFemaleHumansHyperemiaHypertensionMenstrual CycleRisk FactorsSmokingSoftwareUltrasonographyVasodilation

Funding

  • American Heart Association
  • Tobacco-Related Disease Research Program
  • National Institutes of Health
  • NIH Clinical Center
Citations
646
FWCI
20.95
field-weighted impact
References
69
Percentile
100%
vs. same field & year
Citations per year
Cited by
Assessment of flow-mediated dilation in humans: a methodological and physiological guideline
American Journal of Physiology-Heart and Circulatory Physiology · 2010 · 1,439 citations
References
Close relation of endothelial function in the human coronary and peripheral circulations
Journal of the American College of Cardiology · 1995 · 2,031 citations
Effect of a Single High-Fat Meal on Endothelial Function in Healthy Subjects
The American Journal of Cardiology · 1997 · 796 citations
Endothelial function and dysfunction. Part I
Journal of Hypertension · 2005 · 630 citations
Atherosclerosis — An Inflammatory Disease
New England Journal of Medicine · 1999 · 21,632 citations
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