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Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

Diabetes · 1994 · Vol. 43(8) · pp. 1066–1085
C. Ronald Kahn

Abstract

The person who passes urine which is exceedingly sweet, cool, slightly viscid, turbid, and resembling the juices of the sugarcane … suffers from glycosuria. … There are two types of urinary disorders—one, natural due to genetic factors, and the other due to indiscreet living or dietetic indiscretions. The patient suffering from the former is thin, pale, eats less and drinks too much.… The patient with the latter is usually obese, eats a lot, is stout, of sedentary habits and sleeps too much.

Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementGlycosuriaType 2 diabetesAction (physics)Diabetes mellitusInsulinUrineMedicineSedentary lifestyleUrinary systemObesity

MeSH terms

Amino Acid SequenceAnimalsDiabetes Mellitus, Type 2HumansInsulinInsulin ResistanceMolecular Sequence DataPhosphoproteinsProto-Oncogene Proteins p21(ras)ras ProteinsGTP-Binding ProteinsGTP PhosphohydrolasesInsulin Receptor Substrate Proteins

Funding

  • Joslin Diabetes Center
  • National Institutes of Health
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Insulin Action, Diabetogenes, and the Cause of Type II Diabetes · Scinovex