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Altered Proteasomal Function in Sporadic Parkinson's Disease
Experimental Neurology · 2002 · Vol. 179(1) · pp. 38–46
Kevin St. P. McNaught✉(King's College London)Roger Belizaire(Harvard University)Ole Isacson(McLean Hospital)Peter Jenner(King's College London)C. Warren Olanow(Icahn School of Medicine at Mount Sinai)
Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathwaysAutophagy in Disease and TherapySubstantia nigraPars compactaNeurodegenerationProteasomeDopaminergicParkinson's diseaseParkinBiologyNeuroscienceDopamine
MeSH terms
AgedBrainCysteine EndopeptidasesDopamineEnzyme ActivationFemaleHumansMaleMultienzyme ComplexesNeuronsOrgan SpecificityParkinson DiseasePeptide HydrolasesSubstantia NigraProtein Subunits
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References
Anatomic and Disease Specificity of NADH CoQ<sub>1</sub> Reductase (Complex I) Deficiency in Parkinson's Disease
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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Nature Genetics · 1998 · 3,865 citations
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
Annual Review of Biochemistry · 1999 · 1,887 citations
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
Journal of Neurology Neurosurgery & Psychiatry · 1988 · 3,471 citations
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Science · 1997 · 8,181 citations
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