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Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat

American Journal of Physiology-Heart and Circulatory Physiology · 1978 · Vol. 235(3) · pp. H299–H307
K. OhnoK. D. PettigrewС. И. Рапопорт

Abstract

I&c*. 2hyCL $3): H299-~3~1j 1978. -Vascular permeability P in different cerebral regions of the conscious rat was determined, independently of blood flow, for "C tracers of glycerol, mannitol, sucrose, and inulin. A tracer was injected intravenously, arterial plasma concentrations were monitored, and regional brain concentrations were measured at specific times thereafter.

Neuroscience and Neuropharmacology ResearchBiochemical effects in animalsNeurological Disease Mechanisms and TreatmentsPharmaceuticsBlood–brain barrierPharmacologyChemistryPharmaceutical sciencesBrain tumorPharmacokineticsMedicineInternal medicinePathology

MeSH terms

AnimalsBlood-Brain BarrierBrainCell Membrane PermeabilityGlycerolInulinMaleMannitolMathematicsMethodsSucroseRats
Citations
445
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2.99
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References
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
American Journal of Physiology-Legacy Content · 1971 · 1,682 citations
FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
The Journal of Cell Biology · 1967 · 2,614 citations
Partition coefficients and their uses
Chemical Reviews · 1971 · 4,516 citations
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