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The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody
Lara D. Veeken · 2009 · Vol. 49(3) · pp. 433–440
Ran Nakashima✉(Kyoto University)Yoshitaka ImuraShio KobayashiNaoichiro YukawaHajime YoshifujiTakaki NojimaDaisuke KawabataKoichiro OhmuraTakashi UsuiTakao FujiiKatsuya OkawaTsuneyo Mimori
Abstract
The anti-CADM-140 antibody was a marker of DM and intractable ILD and recognized IFIH1/MDA5, which is involved in innate immunity. These findings may give a new insight into the pathogenesis of DM.
T-cell and B-cell ImmunologyImmune Cell Function and InteractionInflammatory Myopathies and DermatomyositisDermatomyositisMedicineMDA5AntibodyReceptorImmunologyVirologyDermatologyInternal medicineBiochemistry
MeSH terms
Interferon-Induced Helicase, IFIH1AdultAmino Acid SequenceAutoantibodiesAutoantigensDermatomyositisHeLa CellsHumansImmunity, InnateMolecular Sequence DataPeptidesBiomarkersIntercellular Signaling Peptides and ProteinsDEAD-box RNA Helicases
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Cited by
Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis
Lara D. Veeken · 2012 · 330 citations
The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): A retrospective study
Journal of the American Academy of Dermatology · 2011 · 545 citations
Immune Signaling by RIG-I-like Receptors
Immunity · 2011 · 1,838 citations
References
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
Proceedings of the National Academy of Sciences · 1979 · 53,787 citations
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