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Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

Molecular Cell · 2000 · Vol. 6(4) · pp. 861–871

David A. Fidock(National Institutes of Health)Takashi Nomura(National Institutes of Health)Angela K. Talley(National Institutes of Health)Roland A. Cooper(National Institutes of Health)Sergey Dzekunov(Georgetown University)Michael T. Ferdig(National Institutes of Health)Lyann M. B. Ursos(Georgetown University)Amar Bir Singh Sidhu(Albert Einstein College of Medicine)Bronwen Naudé(National Institutes of Health)Kirk Deitsch(National Institutes of Health)Xin Su(National Institutes of Health)John C. Wootton(National Institutes of Health)Paul D. Roepe(Georgetown University)Thomas E. Wellems✉(National Institutes of Health)

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Malaria Research and Control Drug Transport and Resistance Mechanisms Antibiotic Resistance in BacteriaBiologyPlasmodium falciparumChloroquinePoint mutationVacuoleTransmembrane proteinMutationMutantGeneGenetics

MeSH terms

Amino Acid SequenceAnimalsChloroquineDigestive SystemDrug ResistanceExonsHumansMembrane ProteinsMolecular Sequence DataPlasmodium falciparumRecombinant ProteinsTetrahydrofolate DehydrogenaseTransfectionVacuolesVerapamil

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