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Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK
Journal of Antimicrobial Chemotherapy · 2009 · Vol. 63(4) · pp. 659–667
Abstract
Ertapenem resistance was exclusively due to combinations of beta-lactamases with impermeability caused by loss of OMPs. Efflux was not implicated and there was no national spread of resistant clones.
Antibiotic Resistance in BacteriaInfections and bacterial resistanceBacterial Identification and Susceptibility TestingErtapenemMicrobiologyEnterobacter cloacaeBiologyKlebsiella pneumoniaePorinEnterobacterKlebsiellaKlebsiella oxytocaEfflux
MeSH terms
ErtapenemAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesDNA, BacterialElectrophoresis, Polyacrylamide GelEnterobacterUnited KingdomHumansKlebsiellaMicrobial Sensitivity TestsPolymerase Chain ReactionMutagenesis, InsertionalElectrophoresis, Gel, Pulsed-FieldSequence Analysis, DNA
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References
Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of<i>Klebsiella pneumoniae</i>
Antimicrobial Agents and Chemotherapy · 2001 · 1,610 citations
Detection of Plasmid-Mediated AmpC β-Lactamase Genes in Clinical Isolates by Using Multiplex PCR
Journal of Clinical Microbiology · 2002 · 1,506 citations
Multiplex PCR for rapid detection of genes encoding acquired metallo- -lactamases
Journal of Antimicrobial Chemotherapy · 2006 · 599 citations
Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum β-lactamases
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