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Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report
American Journal of Psychiatry · 2006 · Vol. 163(11) · pp. 1905–1917
A. John Rush✉(The University of Texas Southwestern Medical Center)Madhukar H. TrivediStephen R. WisniewskiAndrew A. NierenbergJonathan W. StewartDiane WardenGeorge NiedereheMichael E. ThasePhilip W. LavoriBarry D. LebowitzPatrick J. McGrathJerrold F. RosenbaumHarold A. SackeïmDavid J. KupferJames F. LutherMaurizio Fava
Abstract
When more treatment steps are required, lower acute remission rates (especially in the third and fourth treatment steps) and higher relapse rates during the follow-up phase are to be expected. Studies to identify the best multistep treatment sequences for individual patients and the development of more broadly effective treatments are needed.
Treatment of Major DepressionTryptophan and brain disordersMental Health Research TopicsTerm (time)Star (game theory)MedicinePsychologyPsychiatryIntensive care medicineAstrophysicsPhysicsAstronomy
MeSH terms
AdolescentAdultAgedAmbulatory CareAntidepressive AgentsClinical ProtocolsCombined Modality TherapyDepressive Disorder, MajorMajor Depressive DisorderDrug Therapy, CombinationFemaleFollow-Up StudiesHumansMaleMiddle Aged
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