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Age-associated changes in hypothalamic–pituitary–testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study

European Journal of Endocrinology · 2013 · Vol. 168(3) · pp. 445–455

Elizabeth Camacho(University of Manchester)Ilpo Huhtaniemi(Hammersmith Hospital)Terence W O’Neill(University of Manchester)Joseph D. Finn(University of Manchester)Stephen R. Pye(University of Manchester)David M. Lee(University of Manchester)Abdelouahid Tajar(University of Manchester)G. Bártfai(University of Szeged)Steven Boonen(KU Leuven)Felipe F. Casanueva(Instituto de Salud Carlos III)Gianni Forti(University of Florence)Aleksander Giwercman(Skåne University Hospital)Thang S. Han(University College London)Krzysztof Kula(Medical University of Lodz)Brian KeevilMichael E. J. Lean(University of Glasgow)Neil Pendleton(Salford Royal NHS Foundation Trust)Margus Punab(Tartu University Hospital)Dirk Vanderschueren(KU Leuven)Frederick C. W. Wu✉(University of Manchester)_ _

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Abstract

Body weight and lifestyle factors influence HPT axis function in ageing. Weight loss was associated with a rise, and weight gain a fall, in testosterone, FT and SHBG. Weight management appears to be important in maintaining circulating testosterone in ageing men, and obesity-associated changes in HPT axis hormones are reversible following weight reduction.

Hormonal and reproductive studies Sexual Differentiation and Disorders Ovarian function and disordersTestosterone (patch)EndocrinologyInternal medicineAgeingSex hormone-binding globulinMedicineHypothalamic–pituitary–gonadal axisWeight changeLongitudinal studyWeight loss

MeSH terms

AdultAgedAgingEuropeFollow-Up StudiesHumansHypothalamo-Hypophyseal SystemLuteinizing HormoneLife StyleLongitudinal StudiesMaleMiddle AgedProspective StudiesSex Hormone-Binding GlobulinTestis

Citations

383

FWCI

21.55

field-weighted impact

References

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100%

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Citations per year

References

The physical activity scale for the elderly (PASE): Development and evaluation