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A Randomized Trial Comparing Perioperative Chemotherapy and Surgery With Surgery Alone in Resectable Stage IIIA Non-Small-Cell Lung Cancer
JNCI Journal of the National Cancer Institute · 1994 · Vol. 86(9) · pp. 673–680
Jack A. Roth✉(Thoracic Surgery Foundation)Frank V. Fossella(The University of Texas MD Anderson Cancer Center)R. Komaki(Cancer Support Community)Michael Ryan(The University of Texas MD Anderson Cancer Center)Joe B. Putnam(The University of Texas MD Anderson Cancer Center)J. S. Lee(The University of Texas MD Anderson Cancer Center)Hari M. Dhingra(The University of Texas MD Anderson Cancer Center)L. De(The University of Texas MD Anderson Cancer Center)Martin Chasen(The University of Texas MD Anderson Cancer Center)Malcolm H. McGavran(The University of Texas MD Anderson Cancer Center)E. Neely Atkinson(The University of Texas MD Anderson Cancer Center)W. K. Hong(The University of Texas MD Anderson Cancer Center)
Abstract
This clinical trial strengthens the validity of using perioperative chemotherapy in the management of patients with resectable stage IIIA non-small-cell lung cancer. Further investigation of the perioperative chemotherapy strategy in earlier stage lung cancer is warranted.
Lung Cancer Diagnosis and TreatmentLung Cancer Treatments and MutationsMetastasis and carcinoma case studiesMedicinePerioperativeChemotherapySurgeryLung cancerRandomized controlled trialStage (stratigraphy)Induction chemotherapyClinical trialInterim analysis
MeSH terms
Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Non-Small-Cell LungCisplatinCyclophosphamideFemaleHumansLung NeoplasmsMaleMiddle AgedNeoplasm StagingProspective StudiesRemission InductionStatistics as TopicTime FactorsEpirubicin
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