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The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study

Journal of Neurology Neurosurgery & Psychiatry · 2011 · Vol. 83(1) · pp. 102–108

Julie Phukan(Trinity College Dublin)Marwa Elamin✉(Trinity College Dublin)Peter Bede(Trinity College Dublin)Norah Jordan(Beaumont Hospital)Laura Gallagher(Beaumont Hospital)Susan Byrne(Trinity College Dublin)Catherine Lynch(Trinity College Dublin)Niall Pender(Beaumont Hospital)Orla Hardiman(Beaumont Hospital)

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Abstract

Co-morbid dementia occurs in approximately 14% of patients with a new diagnosis of ALS. Cognitive impairment, predominantly but not exclusively in the form executive dysfunction, is present in more than 40% of ALS patients who have no evidence of dementia. Cognitive impairment in ALS is not a universal feature, and its manifestations may be more heterogeneous than previously recognised.

Amyotrophic Lateral Sclerosis Research Alzheimer's disease research and treatments Parkinson's Disease Mechanisms and TreatmentsExecutive dysfunctionDementiaAmyotrophic lateral sclerosisNeuropsychologyFrontotemporal dementiaPopulationCognitionMedicineExecutive functionsPsychology

MeSH terms

AdultAgedAged, 80 and overAmyotrophic Lateral SclerosisCognition DisordersDementiaFemaleHumansMaleMemory DisordersMiddle AgedNeuropsychological TestsProspective StudiesSyndromeCase-Control Studies

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653

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23.20

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Cited by

Global variation in prevalence and incidence of amyotrophic lateral sclerosis: a systematic review and meta-analysis