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Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians

BMJ · 2013 · Vol. 346(may21 1) · pp. f2360–f2360
John D. MathewsAnna ForsytheZoe BradyMarcus W. ButlerStacy GoergenGraham ByrnesGraham G. GilesA. B. WallaceP. R. AndersonTenniel GuiverPaul McGaleTim CainJames G. DowtyAdrian BickerstaffeSarah C. Darby

Abstract

The increased incidence of cancer after CT scan exposure in this cohort was mostly due to irradiation. Because the cancer excess was still continuing at the end of follow-up, the eventual lifetime risk from CT scans cannot yet be determined. Radiation doses from contemporary CT scans are likely to be lower than those in 1985-2005, but some increase in cancer risk is still likely from current scans. Future CT scans should be limited to situations where there is a definite clinical indication, with every scan optimised to provide a diagnostic CT image at the lowest possible radiation dose.

Radiation Dose and ImagingGlobal Cancer Incidence and ScreeningRadioactivity and Radon MeasurementsMedicineRecord linkageCohortIncidence (geometry)CancerConfidence intervalCohort studyCancer registryRate ratioDemography

MeSH terms

AdolescentAustraliaChildChild, PreschoolEpidemiologic MethodsFemaleHumansInfantMaleNeoplasms, Radiation-InducedRadiation DosageSocioeconomic FactorsTime FactorsTomography, X-Ray ComputedAge Distribution
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References
Estimated Risks of Radiation-Induced Fatal Cancer from Pediatric CT
American Journal of Roentgenology · 2001 · 3,219 citations
Computed Tomography — An Increasing Source of Radiation Exposure
New England Journal of Medicine · 2007 · 8,611 citations
International Commission on Radiological Protection
Radiology · 1969 · 2,158 citations
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