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Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Nature Neuroscience · 2006 · Vol. 9(4) · pp. 519–525
Nadia M. TsankovaOlivier BertonWilliam RenthalArvind KumarRachel L. NeveEric J. Nestler
Epigenetics and DNA MethylationTryptophan and brain disordersGenetics and Neurodevelopmental DisordersImipramineHistone deacetylaseDownregulation and upregulationAntidepressantHistoneHistone deacetylase 2Chromatin remodelingBrain-derived neurotrophic factorHistone deacetylase 5Neuroscience

MeSH terms

AcetylationAnimalsAntidepressive AgentsBehavior, AnimalChromatinDepressionDisease Models, AnimalHippocampusHistonesImipramineMaleMethylationMice, Inbred C57BLStress, PsychologicalBrain-Derived Neurotrophic Factor

Funding

  • National Institutes of Health
  • National Institute of Mental Health
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References
The many faces of histone lysine methylation
Current Opinion in Cell Biology · 2002 · 810 citations
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Archives of General Psychiatry · 2000 · 1,977 citations
Neurobiology of Depression
Neuron · 2002 · 3,159 citations
Translating the Histone Code
Science · 2001 · 9,632 citations
Epigenetic programming by maternal behavior
Nature Neuroscience · 2004 · 6,109 citations
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