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Direct evidence that prostate tumors show high sensitivity to fractionation (low α/β ratio), similar to late-responding normal tissue
International Journal of Radiation Oncology*Biology*Physics · 2002 · Vol. 52(1) · pp. 6–13
David J. Brenner✉(Columbia University)Alvaro A. Martinez(Beaumont Hospital, Royal Oak)Gregory K. Edmundson(Beaumont Hospital, Royal Oak)Christina Mitchell(Beaumont Hospital, Royal Oak)Howard D. Thames(The University of Texas MD Anderson Cancer Center)Elwood P. Armour(Beaumont Hospital, Royal Oak)
Prostate Cancer Diagnosis and TreatmentProstate Cancer Treatment and ResearchAdvanced Radiotherapy TechniquesMedicineBrachytherapyProstate cancerProstateRadiation therapyDose fractionationExternal beam radiotherapyNuclear medicineUrologyProstate-specific antigen
MeSH terms
AgedBrachytherapyFollow-Up StudiesHumansIridium RadioisotopesMaleProspective StudiesProstatic NeoplasmsPoisson DistributionTreatment FailureRadiation OncologyDose Fractionation, RadiationRadiotherapy, Conformal
Citations
654
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field-weighted impact
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41
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100%
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References
Time-dose factors in radiotherapy: a review of the human data
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Is α/β for prostate tumors really low?
International Journal of Radiation Oncology*Biology*Physics · 2001 · 630 citations
Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships
International Journal of Radiation Oncology*Biology*Physics · 1982 · 840 citations
Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer
International Journal of Radiation Oncology*Biology*Physics · 1998 · 926 citations
Fractionation and protraction for radiotherapy of prostate carcinoma
International Journal of Radiation Oncology*Biology*Physics · 1999 · 961 citations
Consensus statement: Guidelines for PSA following radiation therapy1
International Journal of Radiation Oncology*Biology*Physics · 1997 · 1,158 citations
Nonparametric Estimation from Incomplete Observations
Journal of the American Statistical Association · 1958 · 38,793 citations
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