review Open AccessTop 10% cited

The importance of efflux pumps in bacterial antibiotic resistance

Journal of Antimicrobial Chemotherapy · 2002 · Vol. 51(1) · pp. 9–11

Mark Webber✉(University of Birmingham)

Abstract

Efflux pumps are transport proteins involved in the extrusionof toxic substrates (including virtually all classes of clinicallyrelevant antibiotics) from within cells into the externalenvironment. These proteins are found in both Gram-positiveand -negative bacteria as well as in eukaryotic organisms.

Antibiotic Resistance in Bacteria Pharmaceutical and Antibiotic Environmental Impacts Enterobacteriaceae and Cronobacter ResearchEffluxAntibiotic resistanceAntibioticsMicrobiologyBacteriaMedicineBiologyGenetics

MeSH terms

AnimalsBacterial ProteinsHumansGene Expression Regulation, BacterialDrug Resistance, BacterialMembrane Transport ProteinsMembrane Transport Modulators

Citations

840

FWCI

3.44

field-weighted impact

References

Percentile

94%

vs. same field & year

Citations per year

Cited by

Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria