review Open AccessTop 1% cited
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Journal of Neuroscience · 2002 · Vol. 22(9) · pp. 3306–3311
Ann E. Kelley✉(University of Wisconsin–Madison)Kent Berridge(University of Michigan–Ann Arbor)
Abstract
Addictive drugs act on brain reward systems, although the brain evolved to respond not to drugs but to natural rewards, such as food and sex. Appropriate responses to natural rewards were evolutionarily important for survival, reproduction, and fitness. In a quirk of evolutionary fate, humans
Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsReceptor Mechanisms and SignalingAddictionNatural (archaeology)Relevance (law)PsychologyNeuroscienceReproductionCognitive scienceBiologyEcology
MeSH terms
AnimalsBrainDopamineHumansNerve NetReinforcement, PsychologyRewardIllicit Drugs
Funding
- National Science Foundation
- National Institute on Drug Abuse
Citations
1,459
FWCI
17.90
field-weighted impact
References
77
Percentile
100%
vs. same field & year
Citations per year
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References
Drug Addiction, Dysregulation of Reward, and Allostasis
Neuropsychopharmacology · 2001 · 2,922 citations
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Neuroscience · 2000 · 974 citations
Opioid modulation of taste hedonics within the ventral striatum
Physiology & Behavior · 2002 · 523 citations
Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Neuroscience · 1991 · 3,233 citations
Conditioned defensive burying: A new paradigm for the study of anxiolytic agents
Pharmacology Biochemistry and Behavior · 1981 · 421 citations
A stereotaxic atlas of the rat brain
Neuroscience · 1980 · 2,799 citations
The involvement of nucleus accumbens dopamine in appetitive and aversive motivation
Behavioural Brain Research · 1994 · 582 citations
Cerebral hemisphere regulation of motivated behavior
Brain Research · 2000 · 854 citations
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