reviewTop 1% cited

Pharmacogenetics: From Bench to Byte— An Update of Guidelines

Clinical Pharmacology & Therapeutics · 2011 · Vol. 89(5) · pp. 662–673

Jesse J. Swen(Leiden University Medical Center)Marga Nijenhuis(Royal Dutch Pharmacists Association)Anthonius de Boer(Utrecht University)L Grandia(Royal Dutch Pharmacists Association)Anke H. Maitland‐van der Zee(Utrecht University)Johannes Mulder(Utrecht University)Gerard A. Rongen(Radboud University Medical Center)Ron H. N. van Schaik(Erasmus University Rotterdam)Tom Schalekamp(Utrecht University)Daan J. Touw(Apotheek Haagse Ziekenhuizen)Jan van der Weide(Rijnstate Hospital)Bob WilffertVera H.M. Deneer(St. Antonius Ziekenhuis)Henk‐Jan Guchelaar✉(Leiden University Medical Center)

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Abstract

Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch Association for the Advancement of Pharmacy established the Pharmacogenetics Working Group with the objective of developing pharmacogenetics-based therapeutic (dose) recommendations. After systematic review of the literature, recommendations were developed for 53 drugs associated with genes coding for CYP2D6, CYP2C19, CYP2C9, thiopurine-S-methyltransferase (TPMT), dihydropyrimidine dehydrogenase (DPD), vitamin K epoxide reductase (VKORC1), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), HLA-B44, HLA-B*5701, CYP3A5, and factor V Leiden (FVL).

Pharmacogenetics and Drug Metabolism Biochemical and Molecular Research Pharmaceutical studies and practicesPharmacogeneticsCYP2C19MedicineThiopurine methyltransferasePharmacologyVKORC1CYP2C9Methylenetetrahydrofolate reductaseInternal medicineGenetics

MeSH terms

AnimalsAryl Hydrocarbon HydroxylasesDrug Administration SchedulePharmaceutical PreparationsHumansPharmacogeneticsPractice Guidelines as TopicDrug-Related Side Effects and Adverse ReactionsCytochrome P-450 CYP2C9

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